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The reversible interconversion of serine and glycine is catalyzed by, either the cytosolic or mitochondrial serine hydroxymethyltransferase (SHMT), SHMT1 or SHMT2, respectively, of which the latter is most prominently expressed in cancer [12,13,14,15]

136, pp

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Combining cagrilintide with semaglutide (as CagriSema) has clinical trial support

Its mechanism also carries meaningful antioxidant and anti-inflammatory activity, tied to how the tripeptide handles copper in oxidative stress contexts, neutralizing lipid peroxidation byproducts and reducing inflammatory mediators

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